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Exploring longevity

Why do we age, and how can the aging process be inhibited?

Recent advances in science have led to a growing body of evidence showing that aging is inextricably linked to “senescence”, the process by which a cell ages and stops dividing but does not die. Over time, large numbers of these cells grow throughout the body. They remain active and release processes that cause inflammation and may damage nearby healthy cells.

Over life, cells are less able to regenerate. And the process begins early. Eight weeks after birth, there is already inability to heal a wound without leaving a scar. Subsequently, in adulthood, the regenerative potential of cells gradually decreases (until death) and is accelerated in contexts of inflammation and diseases.

At the molecular level, several cell signalling pathways have been identified as playing a crucial role in maintaining what we call “cell homeostasis” – the self-regulation of their stability. This means that we could act on the cellular pathways that are intimately connected to senescence (to aging).


Science shows that when cell signalling pathways associated with cell growth and division are activated, this links to an increase in age-related low-grade chronic inflammation and the development of chronic diseases.

In contrast, inhibition of these pathways leads to improved health and longevity, for example with cellular interventions associated with stress resistance.

Longevity is first about your habits

Chronic overeating, lack of proper nutrients, lack of physical activity or sleep issues leads to an imbalance in the cell signalling pathways resulting in overactivation of the growth and division’s processes at the expense of those related to stress resistance that would maintain and regenerate your metabolism.

How wrong lifestyle and nutrients may lead to a higher increase in senescent cells with age? Here is where inflammation strikes.

A cellular imbalance is associated with chronic low-grade age-related inflammation and promotes the emergence of senescent cells while decreasing their elimination by the immune system. Although senescent cells cannot divide, they secrete many pro-inflammatory factors, which, by contamination, contribute to the transformation of cells in their vicinity into senescent cells. This condition favours the development of chronic diseases that impair the quality of life with age.

Longevity is also about science-based solutions that rebalance the body system to reduce age-related chronic inflammation and promote cell regeneration.

Why consider Longevity supplements?

They are advanced nutrition targeted at cellular health. They work on slowing down the hallmarks of aging that cause cellular and molecular damage in the body over time. If we refer to the above science background : they act on nutrient and energy-sensing cell signalling pathways and on senescent cells to reduce their emergence and facilitate their elimination.

Holistic Health Age-Defy contains actives and important nutrients to do this work.

At the top of its science-based ingredients list:

  • Coenzyme Q10: it is naturally made inside our cells to act as an antioxidant, and is essential for cellular energy and maintenance. Its dietary supplementation is known to offer cellular support for the highest energy requirements
  • BetaVia™: nutrient-dense beta-glucans and amino acids that support the immune system and may help cells to produce vital energy
  • Cavacurmin®: highly bioavailable curcumin complex that helps provide potent antioxidant protection
  • Fixentin: known to support a slower cellular senescence
  • Ashwagandha in Niehanyl: anti-inflammatory known to help regulate biological stress reactivity
  • Soybean germ extract: bioactive with one of the richest sources of amino acids that help stabilize cellular functionality and delay age-related damage

And Vitamin E, Vitamin C, Selenium are just a few of the antioxidants in the formula that may support mitochondrial health by balancing free radical damage.

Along a healthy lifestyle, the right nutritional strategies aim to support health maintenance at any age, and secondarily promote long life in good conditions by slowing down the senescence and progression of chronic diseases.