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Fisetin: unlocking the senolytic potential

In the cutting-edge research that could help us all live better for longer, cellular senescence is a topic of growing interest. Senescent cells are cells that, under stress conditions, engage in a process to prevent the replication of damaged DNA. As a result, they stop dividing, then accumulate, releasing compounds in the body that accelerate aging.

Scientific evidence has demonstrated their critical role also in age-related conditions including cardiovascular diseases, diabetes, neurodegenerative diseases, atherosclerosis and cancer. This age-associated cellular decline impacts cells functions, and also our metabolism, our internal homeostasis and our resiliency. Senescent cells are rare in young individuals, but increase with age in multiple tissues, including adipose tissue, brain, skeletal muscle, kidney, and skin.

Did you know that some natural compounds can be helpful and powerful in fighting this cellular decline? They are bioactive agents called “senolytics” and they encourage damaged cells to destroy themselves and thus promote cellular rejuvenation. Fisetin is perhaps the most fascinating of these first-generation molecules, especially because it bears the potential to be an effective antioxidant, anti-inflammatory and immuno-modulating molecule. These are key properties to counter the effect of senescent cells. In fact, senescent cells not only lose the ability to regenerate and repair, but also exert deleterious effects on neighboring cells by secreting a variety of proinflammatory substances described as senescence-associated secretory phenotype (SASP).

Flavonoids, like Fisetin, are a class of polyphenols produced by plants, which are known to have numerous beneficial effects. Polyphenols have been studied for their potential to modulate the production and activity of inflammatory molecules. Fisetin is a bioactive compound found in foods such as apples, strawberries and grapes, and vegetables like tomatoes, cucumbers, and onions.  Interestingly, strawberries have the highest content of Fisetin as compared with other ingredients.

The most promising of the documented Fisetin biological activities resides in the possibility of targeting fundamental aging mechanisms. Although senescent cells resist apoptosis (programmed death), it has been demonstrated that some combinations of senolytics can overcome this resistance. A follow-up screening of the food flavonoids revealed that Fisetin was even more effective than Quercetin and could accomplish the task of reducing senescence markers as a single agent.

Fisetin can be a powerful key natural compound to target aging mechanisms. In Clinique La Prairie’s search for naturally occurring compounds that promote healthy aging and longevity, this ingredient came under the spotlight as a crucial ingredient to be integrated into the proprietary Holistic Complex formula. Targeted in well-defined quantities as Fixentin, you’ll find it in all our supplements. And in the AGE-DEFY evening REGENERESSENCE routine, Fixentin is integrated in a higher concentration (compound explosion) to strongly support cell longevity.

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